AZPD

ARIZONA PARKINSON'S DISEASE CONSORTIUM

The Arizona Parkinson's Disease Consortium (APDC) is a unique collaboration between Arizona researchers located at the Arizona Mayo Clinic Arizona and Banner Sun Health Research Institute (BSHRI). The APDC exploits the unique resources of the BSHRI Brain & Body Donation Program (BBDP: www.brainandbodydonationprogram.org) and the Arizona Study of Aging and Neurodegenerative Disease (AZSAND), a longitudinal clinicopathological study including subjects with Parkinson's disease, Alzheimer's disease and cancer as well as community-recruited normal control subjects. More than 3000 subjects have been enrolled since the study inception in 1987. Of these, more than 1450 donors have expired and their brains have been collected, stored and utilized for research. Since 2005, when the Program expanded to whole-body donation, more than 340 full autopsies have been performed, with banking of tissue from all major organs. Annually, the clinical component of the program performs standardized cognitive, neurologic, and motor assessments of all subjects and more than 90% eventually are autopsied in the BBDPs unique rapid autopsy protocol, with a median postmortem interval of 3 hours. The Consortium has already uncovered exciting results that have revised the pathoanatomical staging of PD, including the first detailed mapping of alpha-synuclein pathology in the peripheral nervous system, the finding that alpha-synuclein phosphorylation and aggregation occurs prior to Lewy body formation and the development of clinical predictive algorithms and biomarkers for PD and dementia in PD. The Consortium also shares banked tissue from subjects with Lewy body disorders with external researchers through the BBDP and its National Brain and Tissue Resource for Parkinson's Disease and Related Disorders, sponsored by the National Institute of Neurological Disorders and Stroke (NINDS).

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